Background. Castleman's Disease is a rare, benign, atypical Iymphoproliferative disorder of unknown etiology characterized by hypervascular lymphoid hyperplasia. It may occur anywhere where there is lymphoid tissue but is most commonly seen in the anterior mediastinum. It may either be localized or disseminated and further subdivided into hyaline-vascular, plasma cell, and mixed histopathological types. Resection of the mass is curative in the majority of cases.
Case. We present a case of disseminated Castleman's disease occurring in a 19 years old female patient who presented with chest pain and chronic non-productive cough, and an intensely enhancing, non-calcified, lobulated mass in the left anterior mediastinum on Chest CT scan.
Conclusion. Clinicians should be aware that Castleman's disease should be considered as one of the differentials in patients presenting with mediastinal mass.